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Glycoconjugates of gadolinium complexes for MRI applications.

Fulton DA, Elemento EM, Aime S, Chaabane L, Botta M, Parker D

Department of Chemistry, University of Durham, South Road, Durham, UK.

Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules.

Published 3 March 2006 in Chem Commun (Camb).
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