MRI Research Today is a free monthly online journal that collates and summarizes the latest research about MRI, including details on magnetic resonance imaging, neuroimaging, brain tumors.

Quantification of physiological and hemodynamic indices using T(1) dynamic contrast-enhanced MRI in intracranial mass lesions.

Singh A, Haris M, Rathore D, Purwar A, Sarma M, Bayu G, Husain N, Rathore RK, Gupta RK

Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, India.

PURPOSE: To estimate precontrast tissue parameter (T(10)) using fast spin echo (FSE) and to quantify physiological and hemodynamic parameters with leakage correction using T(1)-weighted dynamic contrast-enhanced (DCE) perfusion imaging. MATERIALS AND METHODS: Voxel-wise T(10) computation was performed followed by the analysis of T(1)-weighted DCE perfusion data for the conversion of signal intensity time curve to concentration time curve, estimation of hemodynamic and physiological perfusion indices, and a method for leakage correction. Validations of accuracy of the computations have also been carried out. RESULTS: The computed T(10) and hemodynamic perfusion indices in normal white and gray matter were in good agreement with the literature values. Physiological perfusion indices in these regions were found negligible, validating computations. Cerebral blood volume (CBV) values change negligibly over the length of concentration time curve in white matter, gray matter, and lesion (CBV(corrected)), while CBV(uncorrected) (lesion) shows linear increase over time. CONCLUSION: T(1)-weighted DCE perfusion data along with FSE-based T(1) estimation can be used for an accurate estimation of hemodynamic and physiological perfusion indices.

Published 1 October 2007 in J Magn Reson Imaging, 26(4): 871-80.
Full-text of this article is available online (may require subscription).

© 2005-2008 MRI Research Today. All Rights Reserved.