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Muscle MRI in inherited neuromuscular disorders: past, present, and future.

Mercuri E, Pichiecchio A, Allsop J, Messina S, Pane M, Muntoni F

Department of Child Neurology and Psychiatry, Catholic University, Rome, Italy. e.mercuri@ic.ac.uk

Interest in muscle MRI has been largely stimulated in the last few years by the recognition of an increasing number of genetic defects in the field of inherited neuromuscular disorders. Muscle ultrasound (US) and computed tomography (CT) have been used to detect the presence of muscle involvement in patients affected by these disorders, but until recently the use of muscle MRI has been, with a few exceptions, limited to detecting inflammatory forms. The aim of this review is to illustrate how muscle MRI, in combination with clinical evaluation, can contribute to the selection of appropriate genetic tests and more generally in the differential diagnosis of genetically distinct forms of neuromuscular disorders. Possible future applications of muscle MRI are also discussed.

Published 1 February 2007 in J Magn Reson Imaging, 25(2): 433-40.
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